8.cfDNA

Previous cfDNA studies have demonstrated that various features could be derived from cfDNA-seq and cfDNA methylation (cfDNAmet) sequencing data for diagnostic measurement. These features include:
cfDNAmet-seq (Pipelines by PF Bao)
methylation level at promoter region
methylation level at gene body level
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cfDNA-seq (Pipelines by PF Bao)
Mutation (requires deep sequencing depth)
CNV
Nucleosome occupancy footprint (scores: ration/CPM/WPS) (Pipelines by Y Li)
Fragment size profile
End motif pattern
...
Instructions: Calculate cfDNA features by PF Bao
Literatures: cfDNA-seq Analysis - Lu Lab Docs​

Last modified 3mo ago